The gift of healing has been passed through the Epoch family for many generations. Though it’s not hereditary -- the gift must be physically given from one person to another, or else the gift will die out. Epoch was given the gift from his father on his father’s deathbed, and Epoch promised to give it away to his own son when the time came. But Epoch’s son ran away, and with no one else to pass the gift along to, the gift died out along with him. And that’s when something terrible happened.

Because the gift died out, so too did its effect on everyone who had been healed by it. Every person who Epoch ever saved now became “poisoned” by its effects.

These everyday people soon became the epitome of human monsters, killing everyone and everything in their path, and seeking nothing more than to do harm unto the world that they once called home.

With these people -- The Poisoned -- now running amok, it’s up to the Truant family to stop them. Can they overcome their own convoluted histories and work together, or will they remain shackled by the past? Season One focuses exclusively on the Truant family, and their Team's quest to rid the world of a group of human monsters known as The Poisoned. But there are also flashbacks interspersed throughout, as we are shown how Epoch healed each of The Poisoned.

With his release from prison, Duncan Truant is immediatley thrust into a world of monstrous chaos. Believing that Duncan possesses some knowledge on The Poisoned, his mother Matilda orders his early release, on the condition that he joins her team. Duncan hesitantly obeys, even while it seems that his true intention now that he's free is to put his family back together -- his wife Pumpkin and his son Brett. Pumpkin was on a game show several years back, where she won millions, so the days of living in a trailer park are long behind them.